Featured publications

Bar chart showing beta coefficients related to concentration differences in men and women, with higher concentrations in men on the left and in women on the right; blue bars represent men with negative beta values, red bars represent women with positive beta values.
Plot comparing odds ratios for men and women experiencing worse outcomes in different medical reserves, including Peak O2 Extraction, Pulmonary Vascular Reserve, LV Diastolic Reserve, LV Contractile Reserve, and RV Contractile Reserve, with confidence intervals.
Comparison of heart health and infertility risk factors, with a chart showing increased percentage of heart attack risk over time in women with and without history of infertility; icons of women, heart, health device, and reproductive organs.
A scatter plot chart showing the relationship between beta-coefficient and -Log 10 of FDR q-value, with data points in blue on the left indicating lower in early menopause and in red on the right indicating higher in early menopause. The chart is divided into two sections labeled 'Lower in early menopause' and 'Higher in early menopause,' with a dotted vertical line at beta-coefficient zero and dotted horizontal line at FDR q-value 0.1. Key points labeled include IGF-1, CNTN1, Adiposin, Resistin, IGFBP1, Adrenomedullin, and Resistin.
Scatter plot with two groups of data points, one in pink indicating significant results, and one in gray indicating non-significant results. The x-axis represents Odds Ratio of HFpEF, and the y-axis shows -Log(Pvalue). Several labeled points highlight specific data points with associated gene or molecular markers.
Scatter plot showing global longitudinal strain in men and women, with men represented by blue dots and women by red dots; both groups' data points spread across the graph, with trend lines indicating differences in strain by sex and a significance level of P<0.0001.

Contemporary burden of cardiovascular disease in pregnancy: insights from a real-world pregnancy electronic health record cohort

Lau ES, D’Souza V, Zhao Y, Reeder C, Goldberg R, Flores M, Economy KE, Maddah M, Khurshid S, Ellinor PT, and Ho JE. Contemporary Burden of Cardiovascular Disease in Pregnancy: Insights From a Real-World Pregnancy Electronic Health Record Cohort. Circulation. 2025 Oct 14;152(15): 1044-1055.

Prediction of pregnancy-related cardiovascular outcomes using electrocardiogram-based deep learning estimation of cardiorespiratory fitness

Brown L, Zhao Y, D’Souza V, Pace D, James K, Powe C, Churchill T, Economy KE, Maddah M, Ellinor PT, Ho JE, Khurshid S, Guseh SJ, and Lau ES. Prediction of Pregnancy-Related Cardiovascular Outcomes Using Electrocardiogram-Based Deep Learning Estimation of Cardiorespiratory Fitness. JACC Adv. 2026 May, 5 (5): 102764 .

Sex differences in circulating biomarkers of cardiovascular disease

Lau ES, Paniagua SM, Guseh JS, Bhambhani V, Zanni MV, Courchesne P, Lyass A, Larson MG, Levy D, and Ho JE. Sex Differences in Circulating Biomarkers of Cardiovascular Disease. J Am Coll Cardiol. 2019 Sep 24;74(12):1543-1553.

Sex differences in cardiometabolic traits and determinants of exercise capacity in heart failure with preserved ejection fraction

Lau ES, Cunningham T, Hardin KM, Liu E, Malhotra R, Nayor M, Lewis GD, and Ho JE. Sex Differences in Cardiometabolic Traits and Determinants of Exercise Capacity in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2020 Jan 1;5(1):30-37.

Infertility and risk of heart failure in the Women’s Health Initiative

Lau ES, Wang D, Roberts M, Taylor CN, Murugappan G, Shadyab AH, Schnatz PF, Farland LV, Wood MJ, Scott NS, Eaton CB, Ho JE. Infertility and Risk of Heart Failure in the Women’s Health Initiative. J Am Coll Cardiol. 2022 Apr 26, 79 (16): 1594-1603. PMID: 35450577.

Protein biomarkers of early menopause and incident cardiovascular disease

Ramirez MF*, Honigberg M*, Wang D, Parekh JK, Bielawski K, Courchesne P, Larson MD, Levy D, Murabito JM, Ho JE*, Lau ES*. Protein biomarkers of early menopause and incident cardiovascular disease. J Am Heart Assoc. 2023 Aug 7; e028849.

Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Lau ES*, Roshandelpoor A*, Zarbafian S, Wang D, Guseh JS, Allen N, Varadarajan V, Nayor M, Shah RV, Lima JAC, Shah SJ, Yu B, Alotaibi M, Cheng S, Jain M, Lewis GD, Ho JE. Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction. Nat Commun. 2023 Nov 20; 14(1):7557.

Sex differences in left ventricular function and cardiac mechanics

Lau ES, Zhao Y, Benjamin EJ, Ramachandran VS, Xanthakis V, Cheng S, Ho JE. Sex differences in left ventricular function and cardiac mechanics. J Am Heart Assoc. 2024 Jun 18;13(12):e035781